Biological Markers to Predict Cardiac Resynchronization Therapy Effect

How to predict response to cardiac resynchronization therapy?

Cardiac resynchronization therapy (CRT) is considered a major breakthrough in the treatment of patients with end-stage heart failure. Initial studies demonstrated an acute improvement in haemodynamics immediately after CRT, whereas a large number of studies with midterm follow-up (6 months to 1 year) demonstrated an improvement in heart failure symptoms, quality-of-life score, exercise capacity...

Superresponse to cardiac resynchronization therapy.

C ase presentation: A 55-year-old female patient underwent implan-tation of a cardiac resynchronization therapy (CRT) defibrillator 6 years ago owing to nonischemic dilated cardio-myopathy. Her left-ventricular (LV) ejection fraction (EF) was 28% before implantation, her LV end-diastolic volume index (EDVI) was 144 mL/m 2 , and her LV end-systolic volume index (ESVI) was 104 mL/m 2. Her intrins...

Cardiac Simulation to Personalize Cardiac Resynchronization Therapy.

Effect of cardiac resynchronization therapy on reverse remodeling and relation to outcome: multicenter automatic defibrillator implantation trial: cardiac resynchronization therapy.

BACKGROUND Cardiac resynchronization therapy (CRT) plus implantation of an implantable cardioverter defibrillator (ICD) reduced the risk of death or heart failure event in patients with mildly symptomatic heart failure, left ventricular dysfunction, and wide QRS complex compared with an ICD only. We assessed echocardiographic changes in patients enrolled in the MADIT-CRT trial (Multicenter Auto...

Cardiac-resynchronization therapy.

Cardiac resynchronization therapy (CRT) addresses abnormal left ventricular (LV) activation that produces detrimental effects on cardiac systolic and diastolic function. CRT improves symptoms and ventricular performance, promotes reverse remodeling, and decreases mortality and hospitalization in patients with congestive heart failure (CHF). Atrial-synchronized biventricular stimulation reverses...